Caecieleotris morrisi is distinguished from the majority of other sleepers, and all epigean forms in the Western Atlantic, by the absence of eyes and pigmentation. This species is provisionally placed in the Gobiiformes, family Eleotridae, based on a limited number of characters that it shares with other members of the family as currently recognized, e.g., having a mode of six branchiostegals, pelvic fins separated at the base, and procurrent cartilages of the caudal fin elongated posteriorly and extended over the epurals. It differs from the cave-dwelling Bostrychus microphthalmus from Sulawesi by the absence of eyes (vs. present, minute, covered by skin), complete lack of pigmentation (vs. body pale, few melanophores on dorsum), absence of scales on operculum and side of head (vs. present), lower lateral scale count (?32 vs. ?102), fewer transverse scale rows on midside of body (?6 vs. ?31), and absence of pores associated with the cephalic lateralis system (vs. present). It can be diagnosed from the blind species of Oxyeleotris from Indonesia (O. colasi) and Papua New Guinea (O. caeca) in lacking sensory pores on the head associated with the cephalic lateralis system (vs. cephalic sensory pores present, although reduced in comparison to other gobiiform fishes). It differs from the cave species of Typhleotris from Madagascar (T. madagascariensis, T. mararybe, and T. pauliani) in having the head asquamate (vs. scales extending anteriorly onto the head), squamation absent on the venter (vs. fully scaled on the belly as well as laterally below the pectoral fin), scales embedded (especially on anterior half of body) and hard to discern (vs. in prominent rows on the surface of the body and head). Cave-dwelling species of the genus Milyeringa from western Australia have elements of the first dorsal fin reduced (spines II-IV in M. veritas) to absent (M. justitia), versus V-VI in Caecieleotris morrisi; and also have 4-5 total lepidotrichia (first unsegmented) in the pelvic fin, versus six in Caecieleotris morrisi (Ref. 109339).