| Ecosystem | Type | Status | Ref. |
|---|---|---|---|
| Great Lakes | Lake | native | 10294 |
| Lake Erie | Lake | native | 120333 |
| Lake Huron | Lake | native | 120328 |
| Lake Michigan | Lake | native | 86798 |
| Lake Ontario | Lake | native | 120328 |
| Lake St. Clair | Lake | native | 120328 |
| Lake Superior | Lake | introduced | 120875 |
| Mississippi River | River (basin) | native | 5723 |
| Missouri River | River (basin) | native | 78789 |
| Nearctic | Zoogeographic realm | endemic | 5723 |
| Rio Grande | River (basin) | native | 5723 |
| St. Lawrence | River (basin) | native | 5723 |